Recent research has focused on the molecular mechanisms underlying glioblastoma (GBM), particularly in relation to tumor invasion and recurrence. A study by Alshahrany investigates the expression of fibroblast growth factor receptors (FGFRs) in invasive glioblastoma cells, revealing that FGFR1 is significantly expressed while FGFR2 is not. The loss of FGFR1 resulted in a marked reduction in cell migration in vitro and diminished tumor invasion in human glioblastoma xenografts, suggesting that FGFR1 plays a critical role in mediating glioblastoma invasion (ref: Alshahrany doi.org/10.1016/j.canlet.2023.216349/). This finding highlights the potential of targeting FGFR1 as a therapeutic strategy to inhibit glioblastoma progression. Furthermore, the study emphasizes the need for further exploration of FGFR1's signaling pathways to fully understand its role in glioblastoma biology. In addition to invasion, the recurrence of GBM poses a significant challenge in treatment. Wang's study employs single-cell analysis to decode key cell sub-populations and molecular alterations in recurrent GBM. The findings indicate that the mechanisms driving tumor recurrence are complex and involve specific molecular alterations that could serve as new therapeutic targets. The identification of these alterations is crucial for developing effective treatments for recurrent GBM, which currently lacks effective intervention strategies (ref: Wang doi.org/10.1186/s40478-023-01613-x/). Together, these studies underscore the importance of understanding the molecular landscape of glioblastoma to inform future therapeutic approaches.