Precision oncology and personalized cancer treatment guided by genomic and molecular profiling

From November 2025

Fuzuloparib plus apatinib improves PFS in advanced ovarian cancer, ref: Wu doi.org/10.3322/caac.70042/
Sacituzumab tirapazamine shows promising activity in advanced urothelial carcinoma, ref: Zhu doi.org/10.1016/j.annonc.2025.11.013/
DNAJ-PKAc vaccine elicits T cell responses in fibrolamellar hepatocellular carcinoma, ref: Baretti doi.org/10.1038/s41591-025-03995-y/
COVID-19 vaccine may enhance cancer immunotherapy effectiveness, ref: Gnjatic doi.org/10.1038/s41571-025-01105-y/
Ultrasensitive ctDNA monitoring improves lung cancer risk prediction, ref: Black doi.org/10.1016/j.cell.2025.10.020/
Postmastectomy irradiation may be omitted in certain breast cancer patients, ref: Kunkler doi.org/10.1056/NEJMoa2412225/
Antimicrobial peptide delivery as peptibody mRNA shows efficacy against MDR pneumonia, ref: Xue doi.org/10.1038/s41587-025-02928-x/
MED1-driven ecDNA super-enhancers identified as regulatory hubs in cancer, ref: Zhou doi.org/10.1016/j.ccell.2025.10.011/

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