The immunoproteasome impairs neuronal metabolism in multiple sclerosis, leading to neurodegeneration (ref: Woo doi.org/10.1016/j.cell.2025.05.029/)
Chronic traumatic encephalopathy is linked to specific plasma proteomic changes in individuals with repetitive head impacts (ref: Saloner doi.org/10.1186/s13024-025-00860-x/)
AI-based tumor classification shows high concordance with established DNA methylation classes in CNS tumors (ref: Manzl doi.org/10.1038/s43018-025-00971-w/)
MDA5 homeostasis regulated by USP8 plays a critical role in innate immunity and autoimmunity (ref: Zhang doi.org/10.1002/advs.202503865/)
Decellularized human brain tissue provides insights into cell-matrix interactions relevant for neuroregeneration (ref: Bueno doi.org/10.3389/fbioe.2025.1578467/)
Ultra-low-input cfDNA sequencing offers a minimally invasive approach for pediatric brain tumor profiling (ref: Fischer doi.org/10.1186/s40478-025-02024-w/)
ATRX loss in gliomas extends beyond established classifications, indicating a need for refined diagnostic criteria (ref: Tauziède-Espariat doi.org/10.1186/s40478-025-02044-6/)