Microglia-astrocyte crosstalk is crucial for synapse remodeling, with microglia playing a key role in synapse engulfment (ref: Faust doi.org/10.1016/j.cell.2025.08.023/).
Rod-shaped microglia interact with neuronal dendrites to modulate cortical excitability in TDP-43-related neurodegeneration (ref: Xie doi.org/10.1016/j.immuni.2025.08.016/).
The ketogenic diet enhances gut microbiota-derived butyrate production, inhibiting glioma progression and activating microglia (ref: Chen doi.org/10.1016/j.ccell.2025.09.002/).
Senescent-like macrophages influence cognitive aging through migrasome-mediated signaling to microglia (ref: Hu doi.org/10.1038/s43587-025-00956-5/).
Blocking the DP1 receptor reduces microglial senescence and cognitive decline associated with aging (ref: Liu doi.org/10.1111/acel.70228/).
Microglia exhibit polyclonal proliferation in response to ischemic stroke, influencing their functional dynamics (ref: Kikhia doi.org/10.1038/s41467-025-63949-3/).
Therapeutic strategies targeting microglial inflammation show promise in improving outcomes in brain injuries (ref: Ye doi.org/10.1016/j.jare.2025.09.012/).
Microglial interactions with tumor cells are critical for understanding brain tumor progression and developing targeted therapies (ref: Ahn doi.org/10.1158/0008-5472.CAN-25-0237/).