Liquid biopsy technologies for noninvasive disease detection and monitoring using blood and other biofluids
Latest Research Highlights
From November 2025
Ultrasensitive ctDNA detection below 80 parts per million is highly prognostic in NSCLC, improving disease stratification (ref: Black doi.org/10.1016/j.cell.2025.10.020/)
Trastuzumab deruxtecan achieved objective response rates of 62%, 70%, and 79% in HER2-positive metastatic breast cancer (ref: Saura doi.org/10.1016/j.annonc.2025.11.007/)
Elevated plasma ACBP levels predict future lung cancer development in smokers at risk of cardiovascular disease (ref: Fidelle doi.org/10.1186/s12943-025-02507-3/)
Thioketal-incorporated lipid nanoparticles enable efficient mRNA delivery to pancreatic cancer cells (ref: Qiu doi.org/10.1021/jacs.5c19387/)
Single-cell transcriptomic profiling reveals tumor fibrosis in colorectal cancer liver metastasis associated with worse patient outcomes (ref: Deng doi.org/10.1038/s12276-025-01573-3/)
Engineered exosomes serve as nonviral carriers for targeted CRISPR-Cas12a delivery in HIV treatment (ref: Ma doi.org/10.1016/j.ymthe.2025.11.012/)
AI-powered immune profiling predicts outcomes in rectal cancer patients undergoing neoadjuvant chemo-radiotherapy (ref: Shen doi.org/10.1016/j.ebiom.2025.105993/)
Emerging therapeutic strategies highlight the importance of precision medicine and innovative technologies in oncology (ref: Dienstmann doi.org/10.1016/j.esmoop.2025.105888/)