Broad topic covering glioblastoma research

Latest Research Highlights

From November 2025

  • The tumor microbiome in glioblastoma shows distinct microbial signatures by tumor type and location, influencing tumor behavior (ref: Gigi doi.org/10.1038/s43018-025-01073-3/)
  • Cysteine addiction in TMZ-resistant glioblastoma presents a metabolic vulnerability that can be targeted with designer selenium compounds (ref: Tiek doi.org/10.1093/neuonc/)
  • APTw MRI improves diagnostic accuracy for differentiating true progression from pseudoprogression in glioblastoma (ref: Zeyen doi.org/10.1093/neuonc/)
  • Microbubble-enhanced transcranial focused ultrasound shows promise in improving drug delivery for high-grade gliomas (ref: Woodworth doi.org/10.1016/S1470-2045(25)00492-9/)
  • Caspase-8 modulates homologous recombination repair in response to ionizing radiation, suggesting a target for enhancing radiotherapy (ref: Ferri doi.org/10.1016/j.canlet.2025.218120/)
  • Inhibition of sialylation impairs migration and promotes adhesion of glioblastoma cells, indicating a potential therapeutic strategy (ref: Gargano doi.org/10.3390/ijms262110708/)
  • Gamma knife radiosurgery combined with bevacizumab improves survival outcomes in recurrent glioblastoma patients (ref: De Domenico doi.org/10.1016/j.critrevonc.2025.104988/)
  • KYNA administration reduces tumor burden in glioblastoma mouse models, highlighting its potential as a therapeutic target (ref: Chen doi.org/10.1002/advs.202507705/)

Available Research Summaries