Research on extracellular vesicles including exosomes, microvesicles, and their roles in intercellular communication and disease
Latest Research Highlights
From November 2025
miR-499 deficiency in platelet-derived EVs impairs inflammatory cell generation and cardiac remodeling post-MI, highlighting its role in cardiovascular disease, ref: Ohayon-Steckel doi.org/10.1161/CIRCULATIONAHA.124.073527/
Adipocyte-derived EVs can reverse leptin resistance in obesity, suggesting their therapeutic potential in metabolic disorders, ref: Wang doi.org/10.1016/j.cmet.2025.10.005/
A novel modular strategy for EV-mediated CRISPR-Cas9 delivery enhances gene editing efficiency, addressing key challenges in gene therapy, ref: Elsharkasy doi.org/10.1038/s41467-025-65995-3/
CKAP4 identified as a non-invasive biomarker for diabetic nephropathy, demonstrating the diagnostic potential of EVs in metabolic disorders, ref: Zhang doi.org/10.1002/jev2.70208/
Extracellular vesicles facilitate cross-kingdom RNA trafficking, offering innovative solutions for plant protection against fungal pathogens, ref: Niño-Sánchez doi.org/10.1016/j.molp.2025.11.003/
Engineered exosomes improve targeted delivery of CRISPR-Cas12a for HIV-1 editing, showcasing EVs' role in advancing gene therapy, ref: Ma doi.org/10.1016/j.ymthe.2025.11.012/
EVs derived from multiple sclerosis white matter exhibit dysregulation in synaptic and mitochondrial pathways, indicating their role in neurodegenerative diseases, ref: Jank doi.org/10.1002/jev2.70197/